Sodium triacetoxyborohydride → HCID 90013583, compound

Participants

Reaction Steps

To a solution of 290 mg of 6-(4-methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine and 1040 mg N-Boc-(methylamino)acetaldehyde in 5 ml dichloromethane was added 250 mg of sodium triacetoxyborohydride. After 1 h at rt the reaction was diluted with ethyl acetate and water. The phases were separated. The aqueous phase was extracted with ethyl acetate twice. The combined organic phases were dried over sodium sulphate, filtrated and concentrated in vacuo. 1535 mg of a crude product of the title compound were obtained, which was used without purification in the next step.

Provenance & Evidence