Tetrahydrofuran → HCID 118059386, compound

Participants

Reaction Steps

To a solution of 200 mg 6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine in 3 ml abs. THF were added 51 mg ethyl isocyanatoacetate and 51 mg Hünig's base. After 16 h at rt water was added, and the pH was adjusted to neutral. The mixture was extracted with ethyl acetate twice and the combined organic layers were dried and concentrated in vacuo. 70 mg of the title compound were obtained, which were subjected to the subsequent reaction without further purification.

Provenance & Evidence