Ethyl isocyanate → HCID 90014241, compound

Participants

Reaction Steps

To a solution of 290 mg 6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine in 3 ml abs. THF were added 41 mg ethyl isocyanate and 75 mg Hünig's base. After 16 h at rt water was added, and the pH was adjusted to neutral. The mixture was extracted with ethyl acetate twice and the combined organic layers were dried and concentrated in vacuo. 325 mg of the title compound were obtained, which were subjected to the subsequent reaction without further purification.

Provenance & Evidence