Ethyl isocyanate → HCID 178465274, compound

Participants

Reaction Steps

To a solution of 75 mg 3-Fluoro-4-[3-methyl-4-(3-methyl-[1,4]diazepan-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol in 1.5 ml abs. THF were added 15 mg ethyl isocyanate and 26 mg Hünig's base. After 16 h at rt water was added, and the pH was adjusted to neutral. The mixture was extracted with ethyl acetate twice and the combined organic layers were dried and concentrated in vacuo. After purification by HPLC 29 mg (32%) of the title compound were obtained.

Provenance & Evidence