Sodium hydride → HCID 90014275, compound

Participants

Reaction Steps

To 16 mg sodium hydride (60% in mineral oil) in 2 ml of abs. THF were added 80 mg of 6-(4-methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine and after 10 min 17 mg of 2-methoxyacetyl chloride were added. After 16 h at rt the reaction was quenched by the addition of water, the layers were separated and the aqueous layer was extracted with ethyl acetate twice. The combined organic layers were dried and concetrated in vacuo. 93 mg of the title compound were obtained.

Provenance & Evidence