HCID 90013834, compound → HCID 90013594, compound

Participants

Reaction Steps

217 mg of 4-[(R)-4-Benzyl-3-(2,2,2-trifluoro-ethyl)-piperazin-1-ylmethyl]-6-(4-methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine were dissolved in 2.5 ml dichloromethane and 2.5 ml methanol and purged with argon. 22 mg Palladium (10% on charcoal) were added and the mixture was hydrogenated at 5 bar and at r.t. for 1.5 h. The catalyst was filtered off using celite and the solvents were evaporated. 188 mg (100%) of the crude title compound were obtained, which were used in the next step without further purification.

Provenance & Evidence