Hydrochloric Acid → HCID 178434393, compound

Participants

Reaction Steps

188 mg of 6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-[(R)-3-(2,2,2-trifluoro-ethyl)-piperazin-1-ylmethyl]-1H-pyrazolo[3,4-b]pyridine were dissolved in 2 ml of 1,4-dioxane and treated with 2 ml of hydrochloric acid (4M in dry dioxane). After standing at rt for 1.5 h the volatiles were removed in vacuo. The residue was purified by preparative HPLC (C18 column, acetonitrile/water gradient) and 73 mg (50%) of the title compound were obtained.

Provenance & Evidence