4-Hydroxybenzaldehyde → HCID 178497271, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-5-cyclopropylpyrazole (8.95 g), pyruvic acid methyl ester (8.24 g) and 4-hydroxybenzaldehyde (8.87 g) in acetic acid/methanol (v/v=1/1, 120 mL) was stirred at 75° C. for 14 h. The methanol was removed in vacuo, and the remaining mixture was poured unto water, and extracted with ethyl acetate three times. The combined organic phases were washed with brine, dried over magnesium sulfate, filtrated and concentrated in vacuo. The residue was dissolved in 50 ml of acetic acid/methanol (v/v=1/1), heated to reflux for 1 h and cooled to r.t. The precipitated product was isolated by filtration and dried in vacuo at 60° C. 3.80 g (17%) of the title compound were obtained.

Provenance & Evidence