Acetic Acid → HCID 136507827, compound

Participants

Reaction Steps

A mixture of 3-cyclopropyl-6-(4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid methyl ester (11.3 g) and sodium hydroxide solution (1N, 100 mL) in isopropanol (100 mL) was stirred at r.t. for 5 h. The mixture was poured onto ice-water and the pH was adjusted to 5 with acetic acid. The mixture was extracted with dichloromethane three times and the combined organic layers were dried over magnesium sulphate, filtrated and concentrated in vacuo. 10.35 g (95%) of the title compound were obtained.

Provenance & Evidence