Hydrochloric Acid → HCID 178515866, compound

Participants

Reaction Steps

600 mg of 4-[3-cyclopropyl-6-(4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 6 ml of 1,4-dioxane and 2 ml of dichloromethane and treated with 4.8 ml of hydrochloric acid (4M in dry dioxane). After standing at rt for 16 h the volatiles were removed in vacuo. The residue was purified by preparative HPLC (C18 column, acetonitrile/water gradient) and 315 mg (73%) of the title compound were obtained as hydrochloride.

Provenance & Evidence