tert-Butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate → HCID 178434400, compound

HRID 2279170Notes

Reaction equation

HRID 2279170 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[C:19]3[N:21](C4CCCCO4)[N:22]=[C:23]([CH3:24])[C:18]3=[C:17]([C:31](=O)[CH3:32])[CH:16]=2)=[C:11]([F:34])[CH:10]=1)C1C=CC=CC=1.[CH3:35][C@H:36]1[CH2:41][NH:40][CH2:39][C@@H:38]([CH3:42])[N:37]1C(OC(C)(C)C)=O>>[CH3:35][C@@H:36]1[NH:37][C@H:38]([CH3:42])[CH2:39][N:40]([CH:31]([C:17]2[CH:16]=[C:15]([C:12]3[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]=3[F:34])[N:20]=[C:19]3[NH:21][N:22]=[C:23]([CH3:24])[C:18]=23)[CH3:32])[CH2:41]1

Participants

3

Reactant 2

HCID 21021901tert-Butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylateHCID 90013858HCID 90013858, compound

Product 1

HCID 178434400HCID 178434400, compound

Procedure

The title compound was prepared in analogy to Example 97 starting from 1-[6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-ethanone and (2S,6R)-tert-butyl 2,6-dimethylpiperazine-1-carboxylate.

Sources & evidence

ORD record
ord-10c0d35024194e34bab94e70e1aebcec
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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