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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2279173Generated: October 25, 2026

1-Benzyl-2,5-dimethylpiperazine → trans-1-Benzyl-5-methyl-2-phenyl-piperazine

https://huagongshe.com/reaction/2279173

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Benzyl-2,5-dimethylpiperazineHCID 21994188—
Reactanttrans-2-Methyl-5-phenyl-piperazine-1-carboxylic acid tert-butyl esterHCID 40639181—
Producttrans-1-Benzyl-5-methyl-2-phenyl-piperazineHCID 86680328—

Reaction Steps

trans-1-Benzyl-5-methyl-2-phenyl-piperazine was prepared in analogy to the preparation of benzyl-2,5-dimethyl-piperazine (see above) starting form trans-2-methyl-5-phenyl-piperazine-1-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133181B2
Source datasetuspto-grants-2015_09
ORD IDord-b45b945054c64cce9007660b615d3744
Source noteuspto-grants-2015_09