Water → HCID 86680334, compound

HRID 2279179Notes

Reaction equation

HRID 2279179 reaction equation
[NH2:1][CH2:2][C:3](N)([CH3:5])[CH3:4].O[C:8]1([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9]1.[OH2:15]>>[CH3:4][C:3]1([CH3:5])[NH:14][C:13](=[O:15])[C:8]2([CH2:12][CH2:11][CH2:10][CH2:9]2)[NH:1][CH2:2]1

Participants

4

Reactant 3

HCID 962WaterHCID 131282-MethylpropylenediamineHCID 1998551-Hydroxycyclopentanecarbonitrile

Product 1

HCID 86680334HCID 86680334, compoundYield 90%

Procedure

To a solution of 6.1 ml of 1,2-diamino-2-methylpropane in 17 ml water 5.7 ml of 1-hydroxycyclopentane-1-carbonitrile was slowly added. The reaction was kept at reflux for 48 h, and the cooled to r.t. The precipitated product was isolated by suction and washed with water. From the filtrate additional solid could be obtained. The combined solids were freeze-dried and 9.32 g (90%) of the title compound were obtained, which could be used in the next step without further purification.

Workup

  1. temperatureat reflux for 48 h
  2. customThe precipitated product was isolated by suction
  3. washwashed with water
  4. customFrom the filtrate additional solid could be obtained
  5. customThe combined solids were freeze-dried

Sources & evidence

ORD record
ord-0f0e2f5858ab40b0a112586745e11bc3
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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