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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2279184Generated: November 1, 2026

Acetone Cyanohydrin → 1-Benzyl-5-ethyl-2,2,5-trimethyl-piperazine

https://huagongshe.com/reaction/2279184

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetone CyanohydrinHCID 6406—
Reactant2-Methylbutane-1,2-diamineHCID 22666853—
ReactantHCID 64842474HCID 64842474—
Product1-Benzyl-5-ethyl-2,2,5-trimethyl-piperazineHCID 64848332—

Reaction Steps

1-Benzyl-5-ethyl-2,2,5-trimethyl-piperazine was synthesized in analogy to 6-benzyl-8,8-dimethyl-6,9-diaza-spiro[4.5]decane starting from 2-methylbutane 1,2-diamine and acetone cyanohydrin.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133181B2
Source datasetuspto-grants-2015_09
ORD IDord-ec6bd549734a4caeb94a95d35842206f
Source noteuspto-grants-2015_09