HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone Cyanohydrin → 2-Ethyl-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone Cyanohydrin | HCID 6406 | — |
| Reactant | 2-Methylbutane-1,2-diamine | HCID 22666853 | — |
| Reactant | tert-Butyl 8,8-dimethyl-6,9-diazaspiro[4.5]decane-9-carboxylate | HCID 86680337 | — |
| Product | 2-Ethyl-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 90013532 | — |
Reaction Steps
2-Ethyl-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester was synthesized in analogy to 8,8-dimethyl-6,9-diaza-spiro[4.5]decane-9-carboxylic acid tert-butyl ester starting from 2-methylbutane 1,2-diamine and acetone cyanohydrin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133181B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-e5dfccf8ca4940b798b2c586a272661b |
| Source note | uspto-grants-2015_09 |