Propylenediamine → 6-Benzyl-8-methyl-6,9-diazaspiro[4.5]decane

HRID 2279188Notes

Reaction equation

HRID 2279188 reaction equation
[CH2:1]([N:8]1[CH2:17][C:16](C)([CH3:18])[NH:15][CH2:14][C:9]21[CH2:13][CH2:12][CH2:11][CH2:10]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NCC(N)C.OC1(C#N)CCCC1>>[CH2:1]([N:8]1[CH2:17][CH:16]([CH3:18])[NH:15][CH2:14][C:9]21[CH2:10][CH2:11][CH2:12][CH2:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6567PropylenediamineHCID 1998551-HydroxycyclopentanecarbonitrileHCID 64842474HCID 64842474, compound

Product 1

HCID 648461276-Benzyl-8-methyl-6,9-diazaspiro[4.5]decane

Procedure

6-Benzyl-8-methyl-6,9-diaza-spiro[4.5]decane was synthesized in analogy to 6-benzyl-8,8-dimethyl-6,9-diaza-spiro[4.5]decane starting from 1,2-diamino-propane and 1-hydroxycyclopentane-1-carbonitrile.

Sources & evidence

ORD record
ord-f5261a578ca44fdc95c996a64f331c3f
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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