Propylenediamine → HCID 86680338, compound

HRID 2279189Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:17][C:12]2([CH2:16][CH2:15][CH2:14][CH2:13]2)[NH:11][CH2:10][C:9]1(C)[CH3:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].NCC(N)C.OC1(C#N)CCCC1>>[C:1]([O:5][C:6]([N:8]1[CH2:17][C:12]2([CH2:16][CH2:15][CH2:14][CH2:13]2)[NH:11][CH2:10][CH:9]1[CH3:18])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 3

HCID 6567Propylenediamine

HCID 1998551-Hydroxycyclopentanecarbonitrile

HCID 86680337tert-Butyl 8,8-dimethyl-6,9-diazaspiro[4.5]decane-9-carboxylate

Product 1

HCID 86680338HCID 86680338, compound

Procedure

8-Methyl-6,9-diaza-spiro[4.5]decane-9-carboxylic acid tert-butyl ester was synthesized in analogy to 8,8-dimethyl-6,9-diaza-spiro[4.5]decane-9-carboxylic acid tert-butyl ester starting from 1,2-diamino-propane and 1-hydroxycyclopentane-1-carbonitrile.

Sources & evidence

ORD record: ord-1de2a5ca32a54f9482bcc8e24aa40ddc
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133181B2

Reaction notes

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