Acetone Cyanohydrin → 1-Benzyl-5-isopropyl-2,2-dimethyl-piperazine

HRID 2279192Notes

Reaction equation

HRID 2279192 reaction equation
[CH2:1](N1CC(C)(C)NCC21CCCC2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][CH:21]([CH3:26])[CH:22]([NH2:25])[CH2:23][NH2:24].[CH3:27][C:28]([CH3:32])(O)[C:29]#N>>[CH2:1]([N:24]1[CH2:23][CH:22]([CH:21]([CH3:26])[CH3:20])[NH:25][CH2:27][C:28]1([CH3:32])[CH3:29])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6406Acetone CyanohydrinHCID 30642243-Methylbutane-1,2-diamineHCID 64842474HCID 64842474, compound

Product 1

HCID 648378971-Benzyl-5-isopropyl-2,2-dimethyl-piperazine

Procedure

1-Benzyl-5-isopropyl-2,2-dimethyl-piperazine was synthesized in analogy to 6-benzyl-8,8-dimethyl-6,9-diaza-spiro[4.5]decane starting from 3-methyl-butane-1,2-diamine and acetone cyanohydrin.

Sources & evidence

ORD record
ord-5452a8144d4e4fb48686f8257e4ea82c
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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