HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 4,4,4-trichloro-3-oxobutyrate | HCID 77294 | — |
| Reactant | Hydrazinium chloride | HCID 115031 | — |
| Product | Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate | HCID 68571888 | — |
Reaction Steps
4,4,4-Trichloro-3-oxo-butyric acid ethyl ester (Int 8, 1 eq) and H2NNH2.HCl (1.1 eq) are mixed in EtOH. The resulting mixture is refluxed overnight. The mixture is then evaporated and the obtained crude is purified by chromatography to give Int 9 and 5-ethoxy-2H-pyrazole-3-carboxylic acid ethyl ester (Int 10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133210B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-31cc93264c994d118e695060f06583d0 |
| Source note | uspto-grants-2015_09 |