HCID 66980978, compound → HCID 67130092, compound

Participants

Reaction Steps

To a solution of (R)-benzyl 3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate (25d) (0.4 g, 0.99 mmol) in MeOH (10 mL), 10% Pd/C (50 mg) was added and stirred for 2 h under H2 atmosphere. After completion (by TLC), the reaction mixture was filtered through a celite bed, the celite bed was washed with MeOH (10 mL), the combined filtrates were concentrated under reduced pressure to provide the acid 25e (0.280 g, 90%) as a white solid.

Provenance & Evidence