反应详情

To a stirred mixture of 2,6-dibromopyridin-3-ol (47.3 g, 0.188 mol) and but-3-en-1-ol (13.8 g, 0.191 mol) in anhydrous THF (200 mL) at 0° C. was added PPh3 (59.4 g, 0.226 mol), followed by diisopropylazo dicarboxylate (DIAD, 41.77 g, 0.207 mol). The mixture was heated at reflux for 1 hour and then concentrated in vacuo to give a dark brown oil. The oil was dissolved in Ethyl acetate, washed with saturated NaHCO3 solution and brine, dried with Na2SO4, and concentrated in vacuo. Petroleum (300 mL) was added to the crude product mixture. The white solid was removed by filtration, and the filtrate was purified by silica gel chromatography (petroleum/Ethyl acetate, 30/1) to afford compound the title compound as oil (49 g, 85%). 1H NMR (400 Mz, DMSO-d6): δ: 2.62-2.59 (m, 2H); 4.07-4.03 (t, J=6, 2H); 5.22-5.11 (m, 1H); 5.96-5.83 (m, 1H); 7.01 (d, J=7.2); 7.33 (d, J=9.3, 1 H).

1. temperatureThe mixture was heated
2. temperatureat reflux for 1 hour
3. concentrationconcentrated in vacuo
4. customto give a dark brown oil
5. washwashed with saturated NaHCO3 solution and brine
6. dry with materialdried with Na2SO4
7. concentrationconcentrated in vacuo
8. additionPetroleum (300 mL) was added to the crude product mixture
9. customThe white solid was removed by filtration
10. customthe filtrate was purified by silica gel chromatography (petroleum/Ethyl acetate, 30/1)