Hydroxyamine hydrochloride → HCID 123864132, compound

Participants

Reaction Steps

6-[4-methyl-2-(3-pyridyl)thiazol-5-yl]-2,3-dihydropyrano[3,2-b]pyridin-4-one (100 mg, 0.31 mmol), compound H2N—OH.HCl (51 mg, 0.62 mmol) and KOAc (61 mg, 0.62 mmol) were suspended in methanol (3 mL) under N2. The reaction mixture was refluxed for 18 hours and purified by chromatography on silica (Ethyl acetate) to get the pure compound as yellow solid (84 mg, 78%). 1H NMR (400 Mz, CDCl3): 2.68 (s, 3H); 2.97 (t, 2H); 4.00 (s, 3H); 4.28 (t, 2H); 7.55-7.46 (m, 2H); 7.72-7.69 (m, 1H); 8.231-8.29 (m, 2H); 8.66-8.65 (m, 1H); 9.13 (s, 1H). Mpt 148-149° C.

Provenance & Evidence