HCID 87057945, compound → HCID 77231375, compound

Participants

Reaction Steps

3-[2-(tert-butoxycarbonylamino)thiazol-5-yl]sulfanylpropanoic acid (300 mg, 1.0 mmol) was dissolved in polyphosphoric acid (3.08 g, 14 mmol) and heated at 60˜80° C. for 2 hours. The reaction mixture was diluted with ice-cold water and neutralized with NaHCO3 to pH (8˜9) and the solid formed, filtered and washed with water and dried to give the title compound a yellow solid (150 mg, 80% yield)1H NMR (400 Mz, d6-DMSO) δ2.67 (t, 2H), 3.34 (t, 2H), 7.18 (s, 2H).

Provenance & Evidence