Ethanol → HCID 71814872, compound

Participants

Reaction Steps

(Z)-ethyl-4-(4-(2-(difluoroboryl)-4-hydroxybenzylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazole-1-yl)butyrate (1.82 g, 5.0 mmol) was dissolved in water (200 mL), then ethanol (50 mL) and sodium hydroxide (400 mg, 10.0 mmol) were added. The mixture was stirred for 2 hours at r.t., then acidified with aqueous HF solution and extracted with ethyl acetate (3×100 mL), washed with water (1×50 mL) and dried over anhydrous sodium sulfate. The mixture was evaporated and purified by column chromatography (chloroform:ethanol—5:1): 1.29 g. (Yield 77%)

Provenance & Evidence