3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178487966, compound

HRID 2279295Notes

Reaction equation

HRID 2279295 reaction equation
[OH:1][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.C(O[C:19](=[O:30])[NH:20][C@H:21]1[CH2:26][CH2:25][C@H:24]([CH2:27][CH2:28]O)[CH2:23][CH2:22]1)(C)(C)C.[O:31]=[C:32]1[NH:37][C:36]2[CH:38]=[C:39](C(O)=O)[CH:40]=[CH:41][C:35]=2[S:34][CH2:33]1>>[CH3:13][O:12][C:6]1[CH:5]=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:1][CH2:28][CH2:27][C@H:24]3[CH2:23][CH2:22][C@H:21]([NH:20][C:19]([C:39]4[CH:40]=[CH:41][C:35]5[S:34][CH2:33][C:32](=[O:31])[NH:37][C:36]=5[CH:38]=4)=[O:30])[CH2:26][CH2:25]3)=[N:3]2)=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 178453925HCID 178453925, compoundHCID 178487974HCID 178487974, compound

Product 1

HCID 178487966HCID 178487966, compound

Procedure

The title compound is prepared as a white amorphous lyophilizated solid following Scheme 1 and in analogy to Example 2 using 2-hydroxy-7-methoxy-quinoxaline, [trans-4-(2-hydroxy-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-b69af86a4d7e414ca964bed51c16232f
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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