3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 66747162, compound

HRID 2279310Notes

Reaction equation

HRID 2279310 reaction equation
C(O[C:6](=[O:29])[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]2[CH:26]=[N:25][C:24]3[C:19](=[C:20]([O:27][CH3:28])[CH:21]=[CH:22][CH:23]=3)[N:18]=2)[CH2:10][CH2:9]1)(C)(C)C.[O:30]=[C:31]1[NH:36][C:35]2[CH:37]=[C:38](C(O)=O)[CH:39]=[CH:40][C:34]=2[S:33][CH2:32]1>>[CH3:28][O:27][C:20]1[CH:21]=[CH:22][CH:23]=[C:24]2[C:19]=1[N:18]=[C:17]([O:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH:7][C:6]([C:38]3[CH:39]=[CH:40][C:34]4[S:33][CH2:32][C:31](=[O:30])[NH:36][C:35]=4[CH:37]=3)=[O:29])[CH2:9][CH2:10]1)[CH:26]=[N:25]2

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 66747473HCID 66747473, compound

Product 1

HCID 66747162HCID 66747162, compound

Procedure

The title compound is prepared as an off-white lyophilizated powder following Scheme 1 and in analogy to Example 1 using {1-[2-(8-methoxy-quinoxalin-2-yloxy)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-dfe555b86411420f9be386e3d21961fb
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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