HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-1-propanol → 7-chloro-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid {1-[3-(7-methoxy-quinoxalin-2-yloxy)-propyl]-pyrrolidin-3-ylmethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-1-propanol | HCID 12308 | — |
| Reactant | tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate | HCID 4250767 | — |
| Reactant | 2-Chloro-7-methoxyquinoxaline | HCID 12686415 | — |
| Reactant | 7-chloro-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid | HCID 66747474 | — |
| Product | 7-chloro-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid {1-[3-(7-methoxy-quinoxalin-2-yloxy)-propyl]-pyrrolidin-3-ylmethyl}-amide | HCID 66746294 | — |
Reaction Steps
The title compound is prepared as a light yellow lyophilizated powder following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, 3-bromo-propan-1-ol, pyrrolidin-3-ylmethyl-carbamic acid tert-butyl ester and 7-chloro-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133219B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-6b28ff4f65394a4dbbec6b5af2d20f02 |
| Source note | uspto-grants-2015_09 |