6-Methoxy-[1,5]naphthyridine-3-carboxylic acid → HCID 178487904, compound

HRID 2279339Notes

Reaction equation

HRID 2279339 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([OH:15])=[O:14])=[CH:6]2.CO[C:18]([C@H:20]1[CH2:25][CH2:24][C@H:23]([NH:26][CH2:27][CH2:28][S:29][C:30]2[S:31][CH:32]=[CH:33][CH:34]=2)[CH2:22][CH2:21]1)=O>>[S:31]1[CH:32]=[CH:33][CH:34]=[C:30]1[S:29][CH2:28][CH2:27][NH:26][C@H:23]1[CH2:24][CH2:25][C@H:20]([CH2:18][O:14][C:13]([C:7]2[CH:8]=[N:9][C:10]3[C:5]([CH:6]=2)=[N:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=3)=[O:15])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 538928166-Methoxy-[1,5]naphthyridine-3-carboxylic acidHCID 178501227HCID 178501227, compound

Product 1

HCID 178487904HCID 178487904, compound

Procedure

The title compound is prepared as an off-white viscous oil following Scheme 2 and in analogy to Example 28 using 6-methoxy-[1,5]naphthyridine-3-carboxylic acid and trans-4-[2-(thiophen-2-ylsulfanyl)-ethylamino]-cyclohexanecarboxylic acid methyl ester as starting materials.

Sources & evidence

ORD record
ord-bcf67888da8d48a699c8261f29b1c093
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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