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HRID227936

反应详情

EQUATION

反应方程式

HRID 227936 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)CCl
HCID6577

Chloroacetyl chloride

C2H2Cl2O

结构：Cl.NC(=O)[C@@H]1C[C@H](F)CN1
HCID45158917

(4S)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1)

C5H10ClFN2O

PRODUCTS

生成物

1
结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CCl
HCID57518632

(2S,4S)-1-(Chloroacetyl)-4-fluoropyrrolidine-2-carbonitrile

C7H8ClFN2O

PROCEDURE

实验过程

According to the process for producing (2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile described in the publication of WO 02/38541, (2S,4S)-4-fluoropyrrolidine-2-carboxamide hydrochloride (5.00 g) and chloroacetylchloride (2.60 mL) were used to give (2S,4S)-1-(2-chloroacetyl)-4-fluoropyrrolidine-2-carbonitrile (4.96 g).