1-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine → HCID 46853010, compound

HRID 2279363Notes

Reaction equation

HRID 2279363 reaction equation
[Cl:1][C:2]1[C:12]([CH:13]=O)=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][S:9][C:4]=2[CH:3]=1.[CH3:15][O:16][C:17]1[CH:26]=[C:25]2[C:20]([N:21]=[CH:22][C:23]([S:27][CH2:28][CH2:29][N:30]3[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]3)=[N:24]2)=[CH:19][CH:18]=1>>[Cl:1][C:2]1[C:12]([CH2:13][NH:36][CH:33]2[CH2:32][CH2:31][N:30]([CH2:29][CH2:28][S:27][C:23]3[CH:22]=[N:21][C:20]4[C:25](=[CH:26][C:17]([O:16][CH3:15])=[CH:18][CH:19]=4)[N:24]=3)[CH2:35][CH2:34]2)=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][S:9][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 667465301-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamineHCID 86662003HCID 86662003, compound

Product 1

HCID 46853010HCID 46853010, compound

Procedure

The title compound is prepared as a yellow solid (24 mg, 35% yield) following Scheme 3 and in analogy to Example 40 using 7-chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde (30 mg, 0.12 mmol 1.0 eq) and 1-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine (40 mg, 0.12 mmol, 1.0 eq) as starting materials.

Sources & evidence

ORD record
ord-b45e44f50e0b4971ab160d9f5f97f015
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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