3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 46853330, compound

HRID 2279386Notes

Reaction equation

HRID 2279386 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.C(O[C:19](=[O:36])[NH:20][CH:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH:28]([OH:35])[CH2:29][O:30][CH2:31][CH2:32][O:33][CH3:34])[CH2:23][CH2:22]1)(C)(C)C.[O:37]=[C:38]1[NH:43][C:42]2[CH:44]=[C:45](C(O)=O)[CH:46]=[CH:47][C:41]=2[S:40][CH2:39]1>>[CH3:34][O:33][CH2:32][CH2:31][O:30][CH2:29][CH:28]([O:35][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1)[CH2:27][N:24]1[CH2:23][CH2:22][CH:21]([NH:20][C:19]([C:45]2[CH:46]=[CH:47][C:41]3[S:40][CH2:39][C:38](=[O:37])[NH:43][C:42]=3[CH:44]=2)=[O:36])[CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 126864152-Chloro-7-methoxyquinoxalineHCID 66747580HCID 66747580, compound

Product 1

HCID 46853330HCID 46853330, compound

Procedure

The title compound is prepared as a white lyophilizated powder following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, {1-[2-hydroxy-3-(2-methoxy-ethoxy)-propyl]-piperidin-4-yl}-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-d7b5424aa24549e388f32b64142e6729
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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