3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehyde → HCID 46853486, compound

HRID 2279412Notes

Reaction equation

HRID 2279412 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([OH:12])[CH:8]=[N:9]2)=[CH:4][C:3]=1[O:13][CH3:14].C(O[C:20](=O)[NH:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29]O)[CH2:24][CH2:23]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C=O)[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([O:12][CH2:29][CH2:28][N:25]3[CH2:24][CH2:23][CH:22]([NH:21][CH2:20][C:40]4[CH:41]=[CH:42][C:36]5[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)[CH2:27][CH2:26]3)[CH:8]=[N:9]2)=[CH:4][C:3]=1[O:13][CH3:14]

Participants

4

Reactant 3

HCID 109433483-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehydeHCID 45076484[1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl esterHCID 66746690HCID 66746690, compound

Product 1

HCID 46853486HCID 46853486, compound

Procedure

The title compound is prepared as an off-white lyophilizated powder following Scheme 1 and in analogy to Examples 2 and 9 using 7-fluoro-6-methoxy-quinolin-3-ol, [1-(2-hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde as starting materials.

Sources & evidence

ORD record
ord-4ade39a7d85348f7887e1d75dbaf64e7
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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