3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehyde → HCID 66746889, compound

HRID 2279416Notes

Reaction equation

HRID 2279416 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.C(O[C:19](=O)[NH:20][CH:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH:28]([CH:30]2[CH2:32][CH2:31]2)[OH:29])[CH2:23][CH2:22]1)(C)(C)C.[O:34]=[C:35]1[NH:40][C:39]2[CH:41]=[C:42](C=O)[CH:43]=[CH:44][C:38]=2[S:37][CH2:36]1>>[CH:30]1([CH:28]([O:29][C:2]2[CH:11]=[N:10][C:9]3[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=3)[N:3]=2)[CH2:27][N:24]2[CH2:23][CH2:22][CH:21]([NH:20][CH2:19][C:42]3[CH:43]=[CH:44][C:38]4[S:37][CH2:36][C:35](=[O:34])[NH:40][C:39]=4[CH:41]=3)[CH2:26][CH2:25]2)[CH2:31][CH2:32]1

Participants

4

Reactant 3

HCID 109433483-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehydeHCID 126864152-Chloro-7-methoxyquinoxalineHCID 66746365HCID 66746365, compound

Product 1

HCID 66746889HCID 66746889, compound

Procedure

The title compound is prepared as a white lyophilizated powder following Scheme 1 and in analogy to Examples 1 and 9 using 2-chloro-7-methoxy-quinoxaline, [1-(2-cyclopropyl-2-hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde as starting materials.

Sources & evidence

ORD record
ord-d841bc6a3a6046caab74688755d15576
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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