3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178487970, compound

HRID 2279429Notes

Reaction equation

HRID 2279429 reaction equation
C(O[C:6](=[O:30])[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]2[CH:18]=[N:19][C:20]3[C:25]([C:26]=2[OH:27])=[N:24][C:23]([O:28][CH3:29])=[CH:22][CH:21]=3)[CH2:10][CH2:9]1)(C)(C)C.[O:31]=[C:32]1[NH:37][C:36]2[CH:38]=[C:39](C(O)=O)[CH:40]=[CH:41][C:35]=2[S:34][CH2:33]1>>[OH:27][C:26]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[N:24]=2)[N:19]=[CH:18][C:17]=1[O:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH:7][C:6]([C:39]2[CH:40]=[CH:41][C:35]3[S:34][CH2:33][C:32](=[O:31])[NH:37][C:36]=3[CH:38]=2)=[O:30])[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 178487971{1-[2-(4-Hydroxy-6-methoxy-[1,5]naphthyridin-3-yloxy)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 178487970HCID 178487970, compound

Procedure

The title compound is prepared as a white lyophilizated powder following Scheme 1 and in analogy to Example 1 using {1-[2-(4-hydroxy-6-methoxy-[1,5]naphthyridin-3-yloxy)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-efe2f6bd2276495bbc73723cdf7ff1b8
Source dataset
uspto-grants-2015_09
Patent number
US09133219B2

Reaction notes

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