HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3-Fluoro-4-(trifluoromethoxy)phenyl)(oxazol-5-yl)methanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | N-((3-fluoro-4-(trifluoromethoxy)phenyl)(oxazol-5-yl)methyl)-2-methylpropane-2-sulfinamide | HCID 86705473 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (3-Fluoro-4-(trifluoromethoxy)phenyl)(oxazol-5-yl)methanamine hydrochloride | HCID 68294132 | 47.6% |
Reaction Steps
To a solution of 55 (570 g, 1.5 mol) and DCM (10 mL) was added HCl (3.74 mL, 1.5 mol) and the solution stirred for 30 min. The reaction mixture was added dropwise to a stirred solution of ether. The solids were filtered and washed with Et2O to afford 223 mg (47.6%) of (3-fluoro-4-(trifluoromethoxy)phenyl)(oxazol-5-yl)methanamine hydrochloride (56).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133187B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-98b185eda55944be9482130d6e0908be |
| Source note | uspto-grants-2015_09 |