Hydrochloric Acid → HCID 86705475, compound

Participants

Reaction Steps

To a solution of 69a (0.175 g, 0.301 mmol) and DCM (3 mL) was added 6M HCl (0.0110 g, 0.301 mmol) in IPA and the reaction was stirred for 2 h and then poured into satd. aq. Na2CO3 and extracted with DCM. The combined organic fractions were dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with a DCM/MeOH gradient (500:30 to 500:45) to afford 0.030 g (21.3%) of I-43: MS m/z (APCI-pos) M+1=466.

Provenance & Evidence