Hydrochloric Acid → HCID 86705479, compound

Participants

Reaction Steps

To a solution of 92 (912 mg, 2.91 mmol) in THF/H2O (2:1; 15 mL) was added solid LiOH (209 mg, 8.72 mmol). The reaction mixture was stirred at RT for 18 h. The reaction mixture was acidified with 1M HCl to ca. pH 2-3 then twice extracted with EtOAc. The combined EtOAc layers were dried (Na2SO4), filtered and concentrated to afford 902 mg (93.5%) of (S)-4-(tert-butoxycarbonylamino)-3-(4-chloro-3-fluorophenyl)butanoic acid (100) which was used without further purification.

Provenance & Evidence