Hydrochloric Acid → HCID 68294084, compound

Participants

Reaction Steps

To a solution of 102 (632 mg, 1.756 mmol) in 4:1 THF/H2O (5 mL) was added 3M aq. LiOH (5.855 mL, 17.56 mmol). The reaction mixture was stirred at RT for 4 h. The aqueous solution was acidified with 2N HCl to ca. pH 2-3 and then twice extracted with EtOAc. The combined extracts were dried (Na2SO4), filtered, and concentrated to afford 598 mg (98.46%) of (S)-4-(tert-butoxycarbonyl(methyl)amino)-3-(4-chloro-3-fluorophenyl)butanoic acid (104).

Provenance & Evidence