Dimethylformamide → HCID 86705480, compound

Participants

Reaction Steps

To a solution of 72 (102 mg, 0.401 mmol) and 104 (126 mg, 0.364 mmol) and HATU (152 mg, 0.401 mmol) in DMF (5 mL) was added DIPEA (190 μL, 1.09 mmol). The reaction mixture was stirred at RT for 18 h. The reaction was diluted with EtOAc and washed with 1M HCl, satd. aq. NaHCO3, dried (Na2SO4), filtered and concentrated. The crude product was purified by reverse phase column chromatography (SP4) eluting with a MeCN/H2O gradient (5 to 95% MeCN) to afford 102 mg (53.8%) of (S)-tert-butyl 2-(4-chloro-3-fluorophenyl)-4-(2-(isopropylamino)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-4-oxobutyl(methyl)carbamate (106).

Provenance & Evidence