HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → (2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | methyl (S)-lactate | HCID 94386 | — |
| Product | (2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone | HCID 11051776 | 99.7% |
Reaction Steps
(S)-Methyl 2-hydroxypropanoate (30.0 g, 288 mmol) and pyrrolidine (22.5 g, 317 mmol) were stirred at RT for 3 d. The crude product was purified by passing through a SiO2 plug eluting with 80% EtOAc/hexane to afford 41.1 g (99.6%) (S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one (108).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133187B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-fe1ba449fc2b4abe88e5ee84c5516a65 |
| Source note | uspto-grants-2015_09 |