Sodium borohydride → HCID 68294558, compound

Participants

Reaction Steps

To a solution of 126 (400 mg, 1.31 mmol) in MeOH (1 mL) cooled to 0° C. was added slowly NaBH4 (49.4 mg, 1.31 mmol) and the reaction was stirred at RT for 15 min. The reaction was quenched with water and the mixture was extracted with DCM. The organic layer was dried, filtered and concentrated to afford 400 mg (99%) of tert-butyl 5-hydroxy-2-(isopropylamino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (128) which was used with out additional purification.

Provenance & Evidence