HCID 178418361, compound → HCID 178481815, compound

Participants

Reaction Steps

To a stirred solution of 180 (1.00 g, 2.45 mmol) in EtOH/THF (1:1, 35 mL) at RT was added Pearlman's Catalyst (0.172 g, 0.245 mmol). The mixture subjected to a vacuum/purge cycle three times with hydrogen gas and then maintained under 1 atmosphere balloon of hydrogen pressure. After stirring overnight and the reaction was filtered through GF/F filter paper with EtOH and the filtrate was concentrated to afford 0.31 g (90%) of 1-(1-methyl-1H-pyrazol-5-yl)guanidine (182) as a clear glass which was used without further purification: MS m/z (APCI-pos) M+1=140.0.

Provenance & Evidence