反应详情

To a solution of 4-bromo-1,2-dichlorobenzene (2.04 g, 9.01 mmol) and ether (5 mL) cooled to −78° C. was added as a steady stream n-BuLi (3.61 ml, 9.01 mmol) and the reaction was stirred for 10 min then cannulated into a solution of N,2-dimethoxy-N-methylacetamide (1.0 g, 7.51 mmol) and ether (10 mL) which was stirred for an additional 20 min. The reaction was quenched with water and extracted with EtOAc. The organic fractions were dried, filtered and concentrated. The crude product which was purified by SiO2 chromatography eluting with hexane/EtOAc (9:1) to afford 1.30 g (79.0%) of 1-(3,4-dichlorophenyl)-2-methoxyethanone as a white solid (192).

1. stirringwas stirred for an additional 20 min
2. customThe reaction was quenched with water
3. extractionextracted with EtOAc
4. customThe organic fractions were dried
5. filtrationfiltered
6. concentrationconcentrated
7. customThe crude product which was purified by SiO2 chromatography
8. washeluting with hexane/EtOAc (9:1)