Hydrazine hydrate (1:1) → HCID 68294613, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 196 (2.0 g, 5.7 mmol) and THF:MeOH (1:1, 20 mL) at RT was added hydrazine monohydrate (2.9 g, 57 mmol) and the reaction was heated to 50° C. for 18 h. The reaction was cooled to RT, filtered, and the filtrate was poured into water and extracted with DCM. The combined organic fractions were dried (MgSO4), filtered, and concentrated. The crude product was purified by SiO2 chromatography eluting with DCM/MeOH (500:30) to afford 1.1 g (88%) of (S)-1-(3,4-dichlorophenyl)-2-methoxyethanamine as a off-white solid (198).

Provenance & Evidence