Tetrahydrofuran → HCID 86705505, compound

Participants

Reaction Steps

To a solution of 218 (3.8 g, 12 mmol) and THF (40 mL) cooled to −78° C. was added dropwise a solution of ethylmagnesium bromide (5.8 mL, 17 mmol) in ether and the solution was stirred for 1 h, quenched with water, and extracted with Et2O. The crude product was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (35 to 40% EtOAc) to afford 3.5 g (84%) of (R)—N—((R)-1-(3-chloro-4-(trifluoromethoxy)phenyl)propyl)-2-methylpropane-2-sulfinamide (220).

Provenance & Evidence