Hydrochloric Acid → HCID 86705513, compound

Participants

Reaction Steps

To a solution of 240 (0.500 g, 0.898 mmol) and DCM (5 mL) at RT was added 6M HCl in IPA (1.50 mL, 8.98 mmol) and the reaction was stirred for 1 h and then concentrated to dryness. The residue was partitioned between aq. Na2CO3 and DCM. The organic fraction was dried, filtered, and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with a DCM/MeOH gradient (500:30 to 500:35) to afford 0.34 g (85.6%) of I-60 as a mixture of diastereomers: MS m/z (APCI-pos) M+1=442. The racemic mixture was resolved by chiral supercritical fluid chromatography.

Provenance & Evidence