Phthalimide → HCID 86705515, compound

Participants

Reaction Steps

(R)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid and be converted to (R)-tert-butyl 2-(3,4-dichlorobenzoyl)-pyrrolidine-1-carboxylate in accord with steps 1 and 2 of example 11, except in step 2,4-bromo-1-(trifluoromethyl)benzene was replaced with 1-bromo-3,4-dichlorobenzene. Reduction of the ketone with (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole and condensation with isoindoline-1,3 dione can be carried out in accord with procedures in steps 4 and 5 of example 11 to afford (R)-tert-butyl 2-((S)-(3,4-dichlorophenyl)(1,3-dioxoisoindolin-2-yl)methyl)pyrrolidine-1-carboxylate (242).

Provenance & Evidence