Hydrazine hydrate (1:1) → HCID 86705518, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 244 (0.40 g, 1.03 mmol) and MeOH:THF (1:1, 10 mL) was added hydrazine monohydrate (0.514 g, 10.3 mmol) and the reaction was stirred at 50° C. for 18 h. The reaction mixture was poured into water and extracted with DCM. The combined organic extracts were dried (MgSO4), filtered, and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with DCM/MeOH (500:50) to afford 0.130 g (48.8%) of (S)-(3,4-dichlorophenyl)((R)-1-methylpyrrolidin-2-yl)methanamine (246).

Provenance & Evidence