Hydrochloric Acid → HCID 86705521, compound

Participants

Reaction Steps

To a solution of 250 (1.8 g, 4.3 mmol) and DCM (5 mL) was added a solution of HCl in IPA (7.1 mL, 43 mmol) and the reaction was stirred for 1 h. The reaction concentrated to dryness and 4M HCl in dioxane (5 eq) and H2O (1 mL) was added to cleave the cyclohexyl ketal. The reaction was stirred for 1 h and then concentrated to dryness to afford 1.1 g (94%) of (2S,3S)-3-amino-3-(3,4-dichlorophenyl)propane-1,2-diol hydrochloride (252).

Provenance & Evidence