Tetrahydrofuran → HCID 68294110, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 282 (0.5 g, 2.1 mmol) and THF (10 mL) was added BH3—SMe2 (2.1 mL, 4.3 mmol) and the reaction was stirred at 65° C. for 8 h. The reaction was poured into water and extracted with DCM. The combined organic extracts were dried (MgSO4), filtered, and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with EtOAc/MeOH/NH4OH (90/9/1) to afford 0.48 g (94%) of (S)-3-amino-1-(3-fluoro-4-(trifluoromethyl)phenyl)propan-1-ol (284).

Provenance & Evidence